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Article

Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src.

Molecular and cellular biology - 1 Jun 1990

Chan T O, Tanaka A, Bjorge J D, Fujita D J

Abstract excerpt

Chicken embryo fibroblast cells overexpressing activated mutant forms of human pp60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a...

Topics

1-Phosphatidylinositol 4-Kinase
Animals
Avian Sarcoma Viruses
Chick Embryo
Fibroblasts
Genetic Vectors
Humans
Mutation
Oncogene Protein pp60(v-src)
Phosphotransferases
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Transfection

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Identifiers

PMID: 2160600
DOI: 10.1128/mcb.10.6.3280-3283.1990
PMCID: PMC360699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2160600-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src.PMID 2160600Read ↗

Activation of human pp60c-src.Semantic proximity Read ↗

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.Semantic proximity Read ↗

Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c-src.Semantic proximity Read ↗

The amino-terminal region of pp60c-src has a modulatory role and contains multiple sites of tyrosine phosphorylation.Semantic proximity Read ↗

Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.Semantic proximity Read ↗

Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.Semantic proximity Read ↗

Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.Semantic proximity Read ↗

Autophosphorylation of purified c-Src at its primary negative regulation site.Semantic proximity Read ↗

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Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.Semantic proximity Read ↗

Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src.Semantic proximity Read ↗

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