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Article

Molecular analysis of dibasic endoproteolytic cleavage signals.

The Journal of biological chemistry - 25 Oct 1992

Dickinson C J, Daugherty D, Guo Y J, Hughes P, Yamada T

Abstract excerpt

Biologically active peptide hormones are synthesized from larger precursor proteins by a variety of post-translational processing reactions. To characterize these processing reactions further we have expressed preprogastrin in two endocrine cell lines and examined the molecular determinants invol...

Topics

Amino Acid Sequence
Cell Line
Chromatography, Gel
Chromatography, Ion Exchange
Gastrins
Humans
Hydrolysis
Molecular Sequence Data
Mutation
Protein Precursors
Protein Processing, Post-Translational
RNA, Messenger

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PMID: 1400488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1400488-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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