Article
Cell-type specific posttranslational processing of peptides by different pituitary cell lines.
Endocrinology - 1 Jul 1990
Dickerson I M, Mains R E
Abstract excerpt
In order to compare prohormone processing in two distinct pituitary cell types, somatomammotrope cells (GH3) and corticotrope cells (AtT-20) were stably transfected with vectors encoding preproneuropeptide Y (preproNPY) containing four different pairs of basic amino acids at the single endoproteolytic cleavage site: wildtype or KR (lysine-arginine), RR, RK, and KK. The GH-NPY cell lines cleaved proNPY to a...
Topics
- Binding Sites
- Cell Line
- Cytoplasmic Granules
- Epidermal Growth Factor
- Estradiol
- Gene Expression
- Growth Hormone
- Insulin
- Mutation
- Neuropeptide Y
- Peptide Fragments
- Pituitary Gland