Hydrolysis of glycosyl-phosphatidylinositol in response to insulin is reduced in cells bearing kinase-deficient insulin receptors.

doi:10.3109/08977199009071496

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Article

Hydrolysis of glycosyl-phosphatidylinositol in response to insulin is reduced in cells bearing kinase-deficient insulin receptors.

Growth factors (Chur, Switzerland) - 1 Jan 1990

Villalba M, Alvarez J F, Russell D S, Mato J M, Rosen O M

Abstract excerpt

A glycosyl-phosphatidylinositol (GPI) has been previously identified that serves as a precursor of the polar head group that mimics and may mediate some of the intracellular actions of insulin. Since many of the biological activities of insulin may depend upon the activity of the insulin receptor...

Topics

Animals
Cell Line
Glycolipids
Glycosylphosphatidylinositols
Hydrolysis
Insulin
Kinetics
Mutation
Phosphatidylinositols
Protein-Tyrosine Kinases
Receptor, Insulin

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