Article
Peroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2009
Kanzawa Noriyuki, Maeda Yusuke, Ogiso Hideo, Murakami Yoshiko, Taguchi Ryo, Kinoshita Taroh
Abstract excerpt
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) play various roles in cell-cell and cell-environment interactions. GPI is synthesized in the endoplasmic reticulum (ER) from phosphatidylinositol (PI) through step-wise reactions including transfers of monosaccharides and preassembled GPI is transferred en bloc to proteins. Cellular PI contains mostly diacyl glycerol and unsaturated fatty acid in the sn-2...
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