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Article

Characterization of insulin-stimulated protein serine/threonine kinases in CHO cells expressing human insulin receptors with point and deletion mutations.

The Biochemical journal - 1 Oct 1992

Dickens M, Chin J E, Roth R A, Ellis L, Denton R M, Tavaré J M

Abstract excerpt

The activation of insulin-stimulated protein-serine/threonine kinases has been investigated in CHO cell lines transfected with cDNAs encoding either wild-type or mutant human insulin receptors. (1) Insulin treatment of CHO cells over-expressing wild-type insulin receptors resulted in the rapid and substantial (5-10-fold) activation of cytosolic protein kinases which phosphorylated myelin basic protein, Kemptide...

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Identifiers

PMID: 1329727
DOI: 10.1042/bj2870201
PMCID: PMC1133144

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Source receipt: pubmed, retrieved 7 Sept 2026.

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