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Article

LPAR1 and ITGA4 regulate peripheral blood monocyte counts.

Human mutation - 1 Aug 2011

Maugeri Narelle, Powell Joseph E, 't Hoen Peter A C, de Geus Eco J C, Willemsen Gonneke, Kattenberg Mathijs, Henders Anjali K, Wallace Leanne, Penninx Brenda, Hottenga Jouke-Jan, Medland Sarah E, Saviouk Viatcheslav, Martin Nicholas G, Visscher Peter M, van Ommen Gert-Jan B, Frazer Ian H, Boomsma Dorret I, Montgomery Grant W, Ferreira Manuel A R

Abstract excerpt

We recently mapped a quantitative trait locus for monocyte counts to chromosome 9q31 (rs7023923). Here we extend this work by showing with two independent approaches that rs7023923 regulates the expression levels of the nearby LPAR1 gene (P<0.0001), specifically implicating this gene in monocyte development. Furthermore, we tested 10 additional loci identified in the original analysis for replication in 1,122...

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Share to Chromosome Mapping
Share to Gene Expression Profiling
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Share to Polymorphism, Single Nucleotide
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Source

Identifiers

PMID: 21598361
DOI: 10.1002/humu.21536

Genes

ITGA4
LPAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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