Article
Antiphospholipid antibodies in a large population-based cohort: genome-wide associations and effects on monocyte gene expression.
Thrombosis and haemostasis - 4 Jul 2016
Müller-Calleja Nadine, Rossmann Heidi, Müller Christian, Wild Philipp, Blankenberg Stefan, Pfeiffer Norbert, Binder Harald, Beutel Manfred E, Manukyan Davit, Zeller Tanja, Lackner Karl J
Abstract excerpt
The antiphospholipid syndrome (APS) is characterised by venous and/or arterial thrombosis and pregnancy morbidity in women combined with the persistent presence of antiphospholipid antibodies (aPL). We aimed to identify genetic factors associated with the presence of aPL in a population based cohort. Furthermore, we wanted to clarify if the presence of aPL affects gene expression in circulating monocytes. Titres...
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