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Article

The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels.

European heart journal - 1 Apr 2011

Mehta Nehal N, Li Mingyao, William Dilusha, Khera Amit V, DerOhannessian Stephanie, Qu Liming, Ferguson Jane F, McLaughlin Catherine, Shaikh Lalarukh Haris, Shah Rhia, Patel Parth N, Bradfield Jonathan P, He Jing, Stylianou Ioannis M, Hakonarson Hakon, Rader Daniel J, Reilly Muredach P

Abstract excerpt

AIMS: Two single-nucleotide polymorphisms (SNPs), rs1746048 and rs501120, from genome wide association studies of coronary artery disease (CAD) map to chromosome 10q11 ∼80 kb downstream of chemokine CXCL12. Therefore, we examined the relationship between these two SNPs and plasma CXCL12 levels. METHODS AND RESULTS: We tested the association of two SNPs with plasma CXCL12 levels in a two-stage study (n= 2939):...

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Source

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Identifiers

PMID: 21415067
DOI: 10.1093/eurheartj/ehr091
PMCID: PMC3076669

Genes

CXCL12
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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