Article
Cross-linking of DNA through HMGA1 suggests a DNA scaffold.
Nucleic acids research - 1 Sept 2011
Vogel Benjamin, Löschberger Anna, Sauer Markus, Hock Robert
Abstract excerpt
Binding of proteins to DNA is usually considered 1D with one protein bound to one DNA molecule. In principle, proteins with multiple DNA binding domains could also bind to and thereby cross-link different DNA molecules. We have investigated this possibility using high-mobility group A1 (HMGA1) proteins, which are architectural elements of chromatin and are involved in the regulation of multiple DNA-dependent...
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