Article
Oligomerization of Hmo1 mediated by box A is essential for DNA binding in vitro and in vivo.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2016
Kasahara Koji, Higashino Ayako, Unzai Satoru, Yoshikawa Hirofumi, Kokubo Tetsuro
Abstract excerpt
Hmo1, a member of HMGB family proteins in Saccharomyces cerevisiae, binds to and regulates the transcription of genes encoding ribosomal RNA and ribosomal proteins. The functional motifs of Hmo1 include two HMG-like motifs, box A and box B, and a C-terminal tail. To elucidate the molecular roles of the HMG-like boxes in DNA binding in vivo, we analyzed the DNA-binding activity of various Hmo1 mutants using ChIP...
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