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Article

O-GlcNAcylation of High Mobility Group Box 1 (HMGB1) Alters Its DNA Binding and DNA Damage Processing Activities.

Journal of the American Chemical Society - 6 Oct 2021

Balana Aaron T, Mukherjee Anirban, Nagpal Harsh, Moon Stuart P, Fierz Beat, Vasquez Karen M, Pratt Matthew R

Abstract excerpt

Protein O-GlcNAcylation is an essential and dynamic regulator of myriad cellular processes, including DNA replication and repair. Proteomic studies have identified the multifunctional nuclear protein HMGB1 as O-GlcNAcylated, providing a potential link between this modification and DNA damage responses. Here, we verify the protein's endogenous modification at S100 and S107 and found that the major modification...

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Identifiers

PMID: 34546745
DOI: 10.1021/jacs.1c06192
PMCID: PMC8636066

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