Article
High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2008
Lange Sabine S, Mitchell David L, Vasquez Karen M
Abstract excerpt
High mobility group protein B1 (HMGB1) is a multifunctional protein with roles in chromatin structure, transcriptional regulation, V(D)J recombination, and inflammation. HMGB1 also binds to and bends damaged DNA, but the biological consequence of this interaction is not clearly understood. We have shown previously that HMGB1 binds cooperatively with nucleotide excision repair damage recognition proteins to...
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