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Article

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese.

Nature communications - 24 Apr 2018

Okada Yukinori, Momozawa Yukihide, Sakaue Saori, Kanai Masahiro, Ishigaki Kazuyoshi, Akiyama Masato, Kishikawa Toshihiro, Arai Yasumichi, Sasaki Takashi, Kosaki Kenjiro, Suematsu Makoto, Matsuda Koichi, Yamamoto Kazuhiko, Kubo Michiaki, Hirose Nobuyoshi, Kamatani Yoichiro

Abstract excerpt

Understanding natural selection is crucial to unveiling evolution of modern humans. Here, we report natural selection signatures in the Japanese population using 2234 high-depth whole-genome sequence (WGS) data (25.9×). Using rare singletons, we identify signals of very recent selection for the past 2000-3000 years in multiple loci (ADH cluster, MHC region, BRAP-ALDH2, SERHL2). In large-scale genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29691385
DOI: 10.1038/s41467-018-03274-0
PMCID: PMC5915442

Genes

ALDH2
BRAP
SERHL2

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