Article
Polyoma virus small tumor antigen pre-mRNA splicing requires cooperation between two 3' splice sites.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990
Ge H, Noble J, Colgan J, Manley J L
Abstract excerpt
We have studied splicing of the polyoma virus early region pre-mRNA in vitro. This RNA is alternatively spliced in vivo to produce mRNA encoding the large, middle-sized (MTAg), and small (StAg) tumor antigens. Our primary interest was to learn how the 48-nucleotide StAg intron is excised, because...
Topics
- Antigens, Polyomavirus Transforming
- Base Sequence
- Cell Line
- DNA, Viral
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- Plasmids
- Polyomavirus
- RNA Precursors
- RNA Splicing
- RNA, Viral
- Restriction Mapping
- Templates, Genetic
- Transcription, Genetic