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Article

Polyoma virus small tumor antigen pre-mRNA splicing requires cooperation between two 3' splice sites.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990

Ge H, Noble J, Colgan J, Manley J L

Abstract excerpt

We have studied splicing of the polyoma virus early region pre-mRNA in vitro. This RNA is alternatively spliced in vivo to produce mRNA encoding the large, middle-sized (MTAg), and small (StAg) tumor antigens. Our primary interest was to learn how the 48-nucleotide StAg intron is excised, because the length of this intron is significantly less than the apparent minimum established for mammalian introns. Although...

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Identifiers

PMID: 2159146
DOI: 10.1073/pnas.87.9.3338
PMCID: PMC53895

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