Article
Polyadenylylation signal of the mouse thymidylate synthase gene was created by insertion of an L1 repetitive element downstream of the open reading frame.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Harendza C J, Johnson L F
Abstract excerpt
The mouse thymidylate synthase (TS; EC 2.1.1.45) mRNA is unusual in that the poly(A) tail is added at the translation stop codon. To determine the sequence requirements for 3' processing of this mRNA, we constructed TS minigenes with deletion and point mutations in potential regulatory sequences....
Topics
- Animals
- Base Sequence
- Chromosome Deletion
- Codon
- DNA Transposable Elements
- Genes
- Genes, Regulator
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Poly A
- Protein Biosynthesis
- Pseudogenes
- RNA, Messenger