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Article

Mutations in polyomavirus large T affecting immortalization of primary rat embryo fibroblasts.

Virology - 1 May 1990

Larose A, St-Onge L, Bastin M

Abstract excerpt

To clarify the relationship between various functions of the polyomavirus large T antigen and the contribution of this oncogene toward neoplastic transformation, we have analyzed the properties of mutants with in-frame deletions in the second large T exon. dl45, dl96, and dl97 have retained the ability to immortalize primary rat embryo fibroblasts and to trans-activate viral promoters. dl8, dl23, and dl300, which...

Topics

Animals
Antigens, Viral, Tumor
Cell Transformation, Neoplastic
Cells, Cultured
Exons
Fibroblasts
Mutation
Oncogenes
Polyomavirus
Promoter Regions, Genetic
Rats
Transcriptional Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

Source

Identifiers

PMID: 2158701
DOI: 10.1016/0042-6822(90)90234-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2158701-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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