Article
Suppression of the radiation-sensitive phenotype of hamster irs1 and irs2 strains selected for resistance to 3-aminobenzamide.
International journal of radiation biology - 1 May 2001
Ganesh A, Phillips E, Thacker J, Meuth M
Abstract excerpt
PURPOSE: The radiosensitive hamster cell lines irs1 and irs2 have phenotypic similarities to cells defective in the early response to DNA-damaging agents as a result of mutations of the genes encoding poly(ADP-ribose)polymerase (PARP) or ataxia-telangiectasia mutated (ATM). Whether modification of PARP activity through selection of strains resistant to 3-aminobenzamide (3-AB) would affect the radiosensitive...
Topics
- Animals
- Apoptosis
- Benzamides
- Camptothecin
- Cell Line
- Cricetinae
- Cricetulus
- DNA
- DNA Damage
- DNA Replication
- Dose-Response Relationship, Radiation
- Drug Resistance
- Enzyme Inhibitors
- Etoposide
- Humans