Article
Molecular mechanisms of replicational fidelity in Escherichia coli.
Basic life sciences - 1 Jan 1990
Maki H, Akiyama M, Horiuchi T, Sekiguchi M
Abstract excerpt
DNA polymerase III holoenzyme is responsible for chromosomal DNA synthesis in Escherichia coli and seems to be a major determinant of the fidelity of replication of this organism. Among ten different subunits of the holoenzyme, the alpha subunit, encoded by the dnaE gene, has a polymerase activity, while the epsilon subunit, encoded by the dnaQ gene, is a proofreader with a 3'-5' exonuclease activity. Using...
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