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Article

Differential Genetic and Epigenetic Effects of the KLF14 Gene on Body Shape Indices and Metabolic Traits.

International journal of molecular sciences - 9 Apr 2022

Wu Semon, Hsu Lung-An, Teng Ming-Sheng, Chou Hsin-Hua, Ko Yu-Lin

Abstract excerpt

The KLF14 gene is a key metabolic transcriptional transregulator with monoallelic maternal expression. KLF14 variants are only associated with adipose tissue gene expression, and KLF14 promoter methylation is strongly associated with age. This study investigated whether age, sex, and obesity mediate the effects of KLF14 variants and DNA methylation status on body shape indices and metabolic traits. In total, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35456983
DOI: 10.3390/ijms23084165
PMCID: PMC9032945

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