Article
Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230.
Receptors & signal transduction - 1 Jan 1996
Carlson S A, Chatterjee T K, Fisher R A
Abstract excerpt
The platelet-activating factor (PAF) receptor (PAFR) is a G protein-coupled receptor (GPCR) that mediates a diverse array of biological responses to PAF. Recently, we provided evidence that the third intracellular domain (3i) of the rat PAFR (rPAFR) is a critical determinant in its coupling to ph...
Topics
- Alanine
- Amino Acid Sequence
- Animals
- Conserved Sequence
- Dose-Response Relationship, Drug
- Enzyme Activation
- GTP-Binding Proteins
- Glutamic Acid
- Inositol Phosphates
- Mutagenesis, Site-Directed
- Mutation
- Phosphatidylinositol Diacylglycerol-Lyase
- Phosphoinositide Phospholipase C
- Phosphoric Diester Hydrolases
- Platelet Activating Factor
- Platelet Membrane Glycoproteins
- Rats
- Receptors, Cell Surface