Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Expression of Adenosine A3 Receptor in Yeast Utilizing a Chimera with the A2AR C-Terminus.

International journal of molecular sciences - 26 Jun 2020

Jain Abhinav R, Robinson Anne S

Abstract excerpt

The adenosine A3 receptor (A3R) is the only adenosine receptor subtype to be overexpressed in inflammatory and cancer cells and therefore is considered a novel and promising therapeutic target for inflammatory diseases and cancer. Heterologous expression of A3R at levels to allow biophysical characterization is a major bottleneck in structure-guided drug discovery efforts. Here, we apply protein engineering using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Cell Membrane
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Folding

Share to Receptor, Adenosine A2A

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 32604732
DOI: 10.3390/ijms21124547
PMCID: PMC7352405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Expression of Adenosine A3 Receptor in Yeast Utilizing a Chimera with the A2AR C-Terminus.PMID 32604732Read ↗

Molecular dissection of the human A3 adenosine receptor coupling with β-arrestin2.Semantic proximity Read ↗

Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hostsSemantic proximity Read ↗

Reprogramming G protein coupled receptor structure and function.Semantic proximity Read ↗

Characterization of cancer-related somatic mutations in the adenosine A2B receptor.Semantic proximity Read ↗

High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing.Semantic proximity Read ↗

Recovery of histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selectionSemantic proximity Read ↗

Cancer-related somatic mutations alter adenosine A1 receptor pharmacology-A focus on mutations in the loops and C-terminus.Semantic proximity Read ↗

Engineering a human P2X2 receptor with altered ligand selectivity in yeast.Semantic proximity Read ↗

Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling.Semantic proximity Read ↗

Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology.Semantic proximity Read ↗

Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast. Identification of point mutations that "silence" a constitutively active mutant M3 receptor and greatly impair receptor/G protein coupling.Semantic proximity Read ↗

The cytoplasmic end of transmembrane domain 3 regulates the activity of the Saccharomyces cerevisiae G-protein-coupled alpha-factor receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.