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Article

Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes

12 May 2011

Abstract excerpt

BACKGROUND: The identification of filaggrin mutations has contributed towards our understanding of hereditary factors associated with epidermal dysfunction observed in individuals with atopic eczema (AE). However, factors that predispose to acquired filaggrin modulation are not well understood. Interleukin (IL)-22 is upregulated in lesional AE tissue, but its effects on filaggrin expression and genes associated...

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PMID: 21564072
DOI: 10.1111/j.1365-2133.2011.10400.x

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