Article
8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels.
American journal of respiratory cell and molecular biology - 1 Nov 2011
Han Dong-Yun, Nie Hong-Guang, Su Xue-Feng, Shi Xue-Mei, Bhattarai Deepa, Zhao Meimi, Zhao Run-Zhen, Landers Katlin, Tang Hua, Zhang Lin, Ji Hong-Long
Abstract excerpt
Salt absorption via alveolar epithelial Na(+) channels (ENaC) is a critical step for maintaining an airspace free of flooding. Previously, we found that 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na (CPT-cGMP) activated native and heterologous ENaC. To investigate the potential pharmacological relevance, we applied this compound intratracheally to human lungs and found that ex vivo alveolar fluid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.