Article
Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo.
American journal of respiratory cell and molecular biology - 1 Sept 2009
Lazrak Ahmed, Nita Izabella, Subramaniyam Devipriya, Wei Shipeng, Song Weifeng, Ji Hong-Long, Janciauskiene Sabina, Matalon Sadis
Abstract excerpt
A variety of studies have shown that Na(+) reabsorption across epithelial cells depends on the protease-antiprotease balance. Herein, we investigate the mechanisms by which alpha(1)-antitrypsin (A1AT), a major anti-serine protease in human plasma and lung epithelial fluid and lacking a Kunitz domain, regulates amiloride-sensitive epithelial Na(+) channel (ENaC) function in vitro and in vivo. A1AT (0.05 mg/ml = 1...
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