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Article

Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice.

The Journal of physiology - 1 Nov 2004

Egli Marc, Duplain Hervé, Lepori Mattia, Cook Stéphane, Nicod Pascal, Hummler Edith, Sartori Claudio, Scherrer Urs

Abstract excerpt

Pulmonary oedema results from an imbalance between the forces driving fluid into the airspace and the biological mechanisms for its removal. In mice lacking the alpha-subunit of the amiloride-sensitive sodium channel (alphaENaC(-/-)), impaired sodium transport-mediated lung liquid clearance at birth results in neonatal death. Transgenic expression of alphaENaC driven by a cytomegalovirus (CMV) promoter...

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Identifiers

PMID: 15308680
DOI: 10.1113/jphysiol.2004.066704
PMCID: PMC1665279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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