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Article

Nucleoprotein of influenza A virus is a major target of immunodominant CD8+ T-cell responses.

Immunology and cell biology - 1 Feb 2013

Grant Emma, Wu Chao, Chan Kok-Fei, Eckle Sidonia, Bharadwaj Mandvi, Zou Quan Ming, Kedzierska Katherine, Chen Weisan

Abstract excerpt

Influenza A virus causes annual epidemics and sporadic pandemics, resulting in significant morbidity and mortality worldwide. Vaccines are currently available; however, they induce a non-strain-cross protective humoral immune response directed against the rapidly mutating surface glycoproteins, and thus need to be updated annually. As T cells are directed against more conserved internal influenza proteins, a...

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Source

Identifiers

PMID: 23399741
DOI: 10.1038/icb.2012.78

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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