Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening for immunodominant epitopes of SARS-CoV-2 based on CD8+ T cell responses from individuals with HLA-A homozygous alleles.

Molecular immunology - 1 Feb 2025

He Rui, Meng Lingxin, Sun Yuting, Wang Jingsong, Wang Shufeng, Liu Yueping, Fei Lei, Wang Zhongfang, Zhang Qinggao, Wu Yuzhang, Chen Yongwen, Diao Bo

Abstract excerpt

PURPOSE: SARS-CoV-2-specific CD8+ cytotoxic T lymphocytes (CTLs) are crucial in viral clearance, disease progression, and reinfection control. However, numerous SARS-CoV-2 immunodominant CTL epitopes theoretically are still unidentified due to the genetic polymorphism of human leukocyte antigen class I (HLA-I) molecules. METHODS: The CTL epitopes of SARS-CoV-2 were predicted by the epitope affinity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to COVID-19 Vaccines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-A Antigens

Share to Immunodominant Epitopes

Share to Interferon-gamma

Share to SARS-CoV-2

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 39864283
DOI: 10.1016/j.molimm.2025.01.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening for immunodominant epitopes of SARS-CoV-2 based on CD8+ T cell responses from individuals with HLA-A homozygous alleles.PMID 39864283Read ↗

Bioinformatics Prediction and Identification of Sars-Cov-2-Derived Hla-a-Binding T Cell EpitopesSemantic proximity Read ↗

Identification and characterization of an immunodominant SARS-CoV-2-specific CD8 T cell responseSemantic proximity Read ↗

Parallel detection of SARS‐CoV ‐2 epitopes reveals dynamic immunodominance profiles of CD8 + T memory cells in convalescent COVID ‐19 donorsSemantic proximity Read ↗

¿p#1 Characterization of HLA-A*11:01/A*02:01-Restricted SARS-CoV-2 T Cell Epitopes for Vaccine DesignSemantic proximity Read ↗

Sequence-based prediction of SARS-CoV-2 vaccine targets using a mass spectrometry-based bioinformatics predictor identifies immunogenic T cell epitopes.Semantic proximity Read ↗

A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2Semantic proximity Read ↗

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era.Semantic proximity Read ↗

Predicted HLA Class I and Class II Epitopes From Licensed Vaccines Are Largely Conserved in New SARS-CoV-2 Omicron Variant of Concern.Semantic proximity Read ↗

An immunodominance hierarchy exists in CD8 <sup>+</sup> T cell responses to HLA-A*02:01-restricted epitopes identified from the non-structural polyprotein 1a of SARS-CoV-2Semantic proximity Read ↗

SARS-CoV-2 transcriptome analysis and molecular cataloguing of immunodominant epitopes for multi-epitope based vaccine designSemantic proximity Read ↗

Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomicsSemantic proximity Read ↗

Identification of promising SARS-CoV-2 CD8+ and CD4+ T cell epitopes by immunoinformatics approach for a multi-epitope-based vaccine designSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.