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Article

RANKL expression specifically observed in vivo promotes epithelial mesenchymal transition and tumor progression.

The American journal of pathology - 1 Jun 2011

Yamada Tamaki, Tsuda Masumi, Takahashi Tomomi, Totsuka Yasunori, Shindoh Masanobu, Ohba Yusuke

Abstract excerpt

Recent findings have focused attention on the molecular consequences of the microenvironment in tumor progression, but events occurring in cancer cells themselves in response to their ambient conditions remain obscure. Here, we identify receptor activator of nuclear factor κB ligand (RANKL) as a microenvironment-specific factor essential for tumorigenesis in vivo, using head and neck squamous cell carcinoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21561598
DOI: 10.1016/j.ajpath.2011.02.003
PMCID: PMC3124328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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