Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of receptor activator of nuclear factor-kappaB is inversely correlated with metastatic phenotype in breast carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2005

Bhatia Pardeep, Sanders M Melinda, Hansen Marc F

Abstract excerpt

During normal bone remodeling, the receptor activator of nuclear factor-kappaB (RANK) interacts with its ligand RANKL, which is present on pre-osteoclasts, resulting in bone resorption and initiation of new bone formation. When breast cancer metastasizes to bone, normal bone remodeling is disturbed by invasion of tumor cells, resulting in osteolytic lesions. We have studied the expression of both RANK and RANKL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Remodeling
Share to Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Ductal, Breast

Share to Osteoblasts

Share to Osteoclasts

Share to Osteoprotegerin

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Tumor Necrosis Factor

Source

Identifiers

PMID: 15671541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of receptor activator of nuclear factor-kappaB is inversely correlated with metastatic phenotype in breast carcinoma.PMID 15671541Read ↗

RANK-c attenuates aggressive properties of ER-negative breast cancer by inhibiting NF-κB activation and EGFR signalingSemantic proximity Read ↗

RANKL and RANK in Cancer TherapySemantic proximity Read ↗

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cellsSemantic proximity Read ↗

RANK–RANKL signalling in cancerSemantic proximity Read ↗

RANK is an independent biomarker of poor prognosis in estrogen receptor-negative breast cancer and a therapeutic target in patient-derived xenograftsSemantic proximity Read ↗

RANKL/RANK: from bone loss to the prevention of breast cancer.Semantic proximity Read ↗

Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.Semantic proximity Read ↗

The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases.Semantic proximity Read ↗

The association between RANKL and Osteoprotegerin gene polymorphisms with breast cancer.Semantic proximity Read ↗

Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling PathwaysSemantic proximity Read ↗

Prevention of breast cancer by RANKL/RANK blockade.Semantic proximity Read ↗

Polymorphisms in the RANK/RANKL genes and their effect on bone specific prognosis in breast cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.