RANKL and RANK in Cancer Therapy

Abstract excerpt

Receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) are key regulators of mammalian physiology such as bone metabolism, immune tolerance and antitumor immunity, and mammary gland biology. Here, we explore the multiple functions of RANKL/RANK in physiology and pathophysiology and discuss underlying principles and strategies to modulate the RANKL/RANK pathway as a therapeutic target in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Metabolism and Diseases
• Share to Cytokine Signaling Pathways and Interactions
• Share to NF-κB Signaling Pathways