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Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced DNA Damage Promotes Thyroid Cancer Bone Metastasis via Endoplasmic Reticulum Stress and Hedgehog Signaling

2026-08-20

Abstract excerpt

<title>Abstract</title> <p>Objective To investigate the role of RANKL in the initiation and progression of bone metastasis in thyroid cancer. Methods We first retrospectively analyzed clinical data to identify factors associated with bone metastasis. In vitro, we compared the expression of RANK/RANKL signaling components and downstream targets in thyroid cancer cells, and verified the effects by pharmacologic i...

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Literature Corpus work
6054e69b-e51b-5bf3-bba2-e78848029465
DOI
10.21203/rs.3.rs-10596464/v1
Open publication

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Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced DNA Damage Promotes Thyroid Cancer Bone Metastasis via Endoplasmic Reticulum Stress and Hedgehog SignalingDOI 10.21203/rs.3.rs-10596464/v1
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