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Article

RANKL and RANK: From Mammalian Physiology to Cancer Treatment.

Trends in cell biology - 1 Mar 2018

Rao Shuan, Cronin Shane J F, Sigl Verena, Penninger Josef M

Abstract excerpt

The tumor necrosis factor (TNF) receptor RANK (TNFRSF11A) and its ligand RANKL (TNFSF11) regulate osteoclast development and bone metabolism. They also control stem cell expansion and proliferation of mammary epithelial cells via the sex hormone progesterone. As such, RANKL and RANK have been implicated in the onset of hormone-induced breast cancer. Recently, RANK/RANKL were identified as crucial regulators for...

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Share to BRCA1 Protein
Share to Breast Neoplasms
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Epithelial Cells

Share to Neoplastic Stem Cells

Share to RANK Ligand

Share to Receptor Activator of Nuclear Factor-kappa B

Source

Identifiers

PMID: 29241686
DOI: 10.1016/j.tcb.2017.11.001

Genes

BRCA1
TNF
TNFSF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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