Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder.

doi:10.1371/journal.pone.0019011

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Article

Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder.

PloS one - 29 Apr 2011

Frank René A W, McRae Allan F, Pocklington Andrew J, van de Lagemaat Louie N, Navarro Pau, Croning Mike D R, Komiyama Noboru H, Bradley Sophie J, Challiss R A John, Armstrong J Douglas, Finn Robert D, Malloy Mary P, MacLean Alan W, Harris Sarah E, Starr John M, Bhaskar Sanjeev S, Howard Eleanor K, Hunt Sarah E, Coffey Alison J, Ranganath Venkatesh, Deloukas Panos, Rogers Jane, Muir Walter J, Deary Ian J, Blackwood Douglas H, Visscher Peter M, Grant Seth G N

Abstract excerpt

Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role of glutamate receptors and their interacting scaffold proteins, the exons of ten glutamatergic 'hub' genes in 1304 individuals were re-sequenced in case and control samples. No significant difference in the overall number of non-synonymous single nucleotide...

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PMID: 21559497
DOI: 10.1371/journal.pone.0019011
PMCID: PMC3084736

Genes

GRM1

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