Article

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

2020-09-18

Abstract excerpt

By meta-analyzing the whole-exomes of 24,248 cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for schizophrenia (odds ratios 3 - 50, P < 2.14 × 10 -6 ), and 32 genes at a FDR < 5%. These genes have the greatest expression in central nervous system neurons and have diverse molecular functions that include the formation, structure, and function of...

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Literature Corpus work: 4d025377-0512-5eea-a604-cf260da5016d
DOI: 10.1101/2020.09.18.20192815

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