Article
Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.
Molecular psychiatry - 1 Jan 2002
Williams N M, Bowen T, Spurlock G, Norton N, Williams H J, Hoogendoorn B, Owen M J, O'Donovan M C
Abstract excerpt
The glutamatergic system is the major excitatory neurotransmitter system in the CNS. Glutamate receptors, and in particular N-methyl-D-aspartate (NMDA) receptors, have been proposed as mediators of many common neuropsychiatric phenotypes including cognition, psychosis, and degeneration. We have reconstructed the genomic structure of all five genes encoding NMDA receptors in silico. We screened each for sequence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.