Article
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
Science (New York, N.Y.) - 25 Apr 2008
Walsh Tom, McClellan Jon M, McCarthy Shane E, Addington Anjené M, Pierce Sarah B, Cooper Greg M, Nord Alex S, Kusenda Mary, Malhotra Dheeraj, Bhandari Abhishek, Stray Sunday M, Rippey Caitlin F, Roccanova Patricia, Makarov Vlad, Lakshmi B, Findling Robert L, Sikich Linmarie, Stromberg Thomas, Merriman Barry, Gogtay Nitin, Butler Philip, Eckstrand Kristen, Noory Laila, Gochman Peter, Long Robert, Chen Zugen, Davis Sean, Baker Carl, Eichler Evan E, Meltzer Paul S, Nelson Stanley F, Singleton Andrew B, Lee Ming K, Rapoport Judith L, King Mary-Claire, Sebat Jonathan
Abstract excerpt
Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. We hypothesize that individually rare structural variants contribute to the illness. Microdeletions and microduplications >100 kilobases were identified by microarray comparative genomic hybridization of genomic DNA from 150 individuals with schizophrenia and 268 ancestry-matched controls. All variants were...
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