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Article

Age-related retinopathy in NRF2-deficient mice.

PloS one - 29 Apr 2011

Zhao Zhenyang, Chen Yan, Wang Jian, Sternberg Paul, Freeman Michael L, Grossniklaus Hans E, Cai Jiyang

Abstract excerpt

BACKGROUND: Cumulative oxidative damage is implicated in the pathogenesis of age-related macular degeneration (AMD). Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays key roles in retinal antioxidant and detoxification responses. The purposes of this study were to determine whether NRF2-deficient mice would develop AMD-like retinal pathology with aging and to explore the...

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Identifiers

PMID: 21559389
DOI: 10.1371/journal.pone.0019456
PMCID: PMC3084871

Genes

RPE
ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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