AAV NRF2 Gene Therapy Preserves Retinal Structure and Function in Rodent Models of Oxidative Damage

Abstract excerpt

Dry age-related macular degeneration is the most frequent cause of visual impairment in individuals over age 50 in developed countries. It is characterized by subretinal deposits of oxidized proteins and lipids and results in progressive loss of high acuity vision. One major risk factor is smoking, which causes oxidative stress in many tissues, including the eye. We previously showed that an adeno-associated viral...

Topics

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• Acetaminophen
• Dependovirus
• Gene Order
• Intravitreal Injections
• Models, Animal
• NF-E2-Related Factor 2
• Ocular Diseases and Behçet’s Syndrome
• Retinal Diseases and Treatments

Identifiers and source

Literature Corpus work

a349ef17-978d-5486-a624-a6cd686f22a5

DOI

10.1101/2025.07.09.663952