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Article

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice.

International journal of molecular sciences - 8 Feb 2021

Blasiak Janusz, Koskela Ali, Pawlowska Elzbieta, Liukkonen Mikko, Ruuth Johanna, Toropainen Elisa, Hyttinen Juha M T, Viiri Johanna, Eriksson John E, Xu Heping, Chen Mei, Felszeghy Szabolcs, Kaarniranta Kai

Abstract excerpt

Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness worldwide in the elderly population. In our previous studies, we found that deficiencies in the nuclear factor, erythroid 2 like 2 (NFE2L2) and peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α) genes caused AMD-like pathological phenotypes in mice. In the present work, we show hijacked...

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Identifiers

PMID: 33567500
DOI: 10.3390/ijms22041684
PMCID: PMC7915526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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