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Article

Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target

5 Nov 2018

Abstract excerpt

Age-related macular degeneration is one of the leading causes of vision loss in the elderly. Genetics, environmental insults, and age-related issues are risk factors for the development of the disease. All these risk factors are linked to the induction of oxidative stress. In young subjects retinal pigment epithelial cells mitigate reactive oxygen generation by the elimination of dysfunctional mitochondria, via...

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PMID: 30455645
DOI: 10.3389/fphar.2018.01280

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