Article

AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD

2026-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Oxidative stress is proposed to be a driver of age-related diseases. Age-related macular degeneration is one such disease, where the retinal pigment epithelium (RPE) is affected early in the disease. Vasculature damage also occurs, sometimes preceding RPE damage. To model some aspects of dry AMD, we used the NaIO3 mouse model of oxidative damage. Disruption of the deep retinal vascular plexus, d...

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Literature Corpus work: 05eee19a-911f-5526-891c-28266682c5c7
DOI: 10.64898/2026.05.13.724735

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