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Article

Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas

15 Jun 2011

Abstract excerpt

Curative eradication of all cells within carcinomas is seldom achievable with chemotherapy alone. This limitation may be partially attributable to tumor cell subpopulations with intrinsic resistance to current drugs. Within squamous cell carcinoma (SCC) cell lines, we previously characterized a subpopulation of mesenchymal-like cells displaying phenotypic plasticity and increased resistance to both cytotoxic and...

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PMID: 21558812
DOI: 10.4161/cc.10.12.15883

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