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Article

Evidence for mesenchymal-like sub-populations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity.

Oncogene - 22 Jul 2010

Basu D, Nguyen T-T K, Montone K T, Zhang G, Wang L-P, Diehl J A, Rustgi A K, Lee J T, Weinstein G S, Herlyn M

Abstract excerpt

Variable drug responses among malignant cells within individual tumors may represent a barrier to their eradication using chemotherapy. Carcinoma cells expressing mesenchymal markers resist conventional and epidermal growth factor receptor (EGFR)-targeted chemotherapy. In this study, we evaluated whether mesenchymal-like sub-populations within human squamous cell carcinomas (SCCs) with predominantly epithelial...

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Source

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Identifiers

PMID: 20498638
DOI: 10.1038/onc.2010.170
PMCID: PMC3039880

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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