Article
Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity.
Cancer research - 15 Sept 2015
Bernardo M Margarida, Kaplun Alexander, Dzinic Sijana H, Li Xiaohua, Irish Jonathan, Mujagic Adelina, Jakupovic Benjamin, Back Jessica B, Van Buren Eric, Han Xiang, Dean Ivory, Chen Yong Q, Heath Elisabeth, Sakr Wael, Sheng Shijie
Abstract excerpt
Future curative cancer chemotherapies have to overcome tumor cell heterogeneity and plasticity. To test the hypothesis that the tumor suppressor maspin may reduce microenvironment-dependent prostate tumor cell plasticity and thereby modulate drug sensitivity, we established a new schematic combination of two-dimensional (2D), three-dimensional (3D), and suspension cultures to enrich prostate cancer cell...
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