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Article

TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype.

Cancer research - 1 Jul 2011

Asiedu Michael K, Ingle James N, Behrens Marshall D, Radisky Derek C, Knutson Keith L

Abstract excerpt

Breast cancer recurrence is believed to be caused by a subpopulation of cancer cells that possess the stem cell attribute of treatment resistance. Recently, we and others have reported the generation of breast cancer stem cells (BCSC) by epithelial-mesenchymal transition (EMT), although the physiologic process by which these cells may arise in vivo remains unclear. We show here that exposure of tumor cells to...

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Source

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Identifiers

PMID: 21555371
DOI: 10.1158/0008-5472.CAN-10-4554
PMCID: PMC3129359

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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