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Article

Emerging Roles of Claudins in Human Cancer

4 Sept 2013

Abstract excerpt

Claudins are major integral membrane proteins of tight junctions. Altered expression of several claudin proteins, in particular claudin-1, -3, -4 and -7, has been linked to the development of various cancers. Although their dysregulation in cancer suggests that claudins play a role in tumorigenesis, the exact underlying mechanism remains unclear. The involvement of claudins in tumor progression was suggested by...

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PMID: 24009024
DOI: 10.3390/ijms140918148

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