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Article

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype.

Journal of cellular physiology - 1 Nov 2010

Storci Gianluca, Sansone Pasquale, Mari Sara, D'Uva Gabriele, Tavolari Simona, Guarnieri Tiziana, Taffurelli Mario, Ceccarelli Claudio, Santini Donatella, Chieco Pasquale, Marcu Kenneth B, Bonafè Massimiliano

Abstract excerpt

Extracellular and intracellular mediators of inflammation, such as tumor necrosis factor alpha (TNFα) and NF-kappaB (NF-κB), play major roles in breast cancer pathogenesis, progression and relapse. SLUG, a mediator of the epithelial-mesenchymal transition process, is over-expressed in CD44(+)/CD24(-) tumor initiating breast cancer cells and in basal-like carcinoma, a subtype of aggressive breast cancer endowed...

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PMID: 20509143
DOI: 10.1002/jcp.22264
PMCID: PMC2939957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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