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Article

Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development.

Leukemia - 1 Jan 2016

Roncero A M, López-Nieva P, Cobos-Fernández M A, Villa-Morales M, González-Sánchez L, López-Lorenzo J L, Llamas P, Ayuso C, Rodríguez-Pinilla S M, Arriba M C, Piris M A, Fernández-Navarro P, Fernández A F, Fraga M F, Santos J, Fernández-Piqueras J

Abstract excerpt

The JAK-STAT pathway has a substantial role in lymphoid precursor cell proliferation, survival and differentiation. Nonetheless, the contribution of JAK2 to T-cell lymphoblastic lymphoma (T-LBL) development remains poorly understood. We have identified one activating TEL-JAK2 translocation and four missense mutations accumulated in 2 out of 16 T-LBL samples. Two of them are novel JAK2 mutations and the other two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26216197
DOI: 10.1038/leu.2015.202
PMCID: PMC4705429

Genes

JAK2
LMO2
SOCS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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