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Article

Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5.

Experimental hematology - 1 Jul 2011

Ingram Richard M, Valeaux Stephanie, Wilson Nicola, Bouhlel M Amine, Clarke Deborah, Krüger Imme, Kulu Divine, Suske Guntram, Philipsen Sjaak, Tagoh Hiromi, Bonifer Constanze

Abstract excerpt

OBJECTIVE: The transcription factor PAX5 is essential for the activation of B-cell-specific genes and for the silencing of myeloid-specific genes. We previously determined the molecular mechanism by which PAX5 silences the myeloid-specific colony-stimulating-factor-receptor (Csf1R) gene and showed that PAX5 directly binds to the Csf1r promoter as well as to an intronic enhancer that generates an antisense...

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Source

Identifiers

PMID: 21549805
DOI: 10.1016/j.exphem.2011.04.004

Genes

PAX5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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